报告人: 郑利民教授，院长 中山大学生命学院

　　时间: 2015 年1月8日下午16：00-17：30

　　地点: 动物所A401会议室

　　郑利民:“长江学者”特聘教授；杰青获得者 1984年毕业于上海医科大学随后在附属华山医院任住院和总住院医生。1994年获荷兰Leiden大学免疫学博士；1999年被瑞典国家研究院聘为助理教授。2002年底入选中山大学“百人计划”，2004年获国家杰出青年基金，2009年被聘为教育部“长江学者”特聘教授。现任中山大学生命科学院副院长，肿瘤医院生物治疗中心主任和中山大学肝癌研究所所长。多年来一直从事人免疫细胞信号调控研究，在国际期刊发表论文40余篇，总影响因子220余点。目前以肝癌为主要模型，结合临床样本和实验模型来研究间质免疫细胞（土壤）与癌细胞（种子）之间的相互作用和潜在机制，探讨以间质免疫细胞作为肿瘤分子分期和治疗靶标的可行性。

　　Selected Recent Publications:

　　1. Wu, W. C., … Zheng, L. Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients. Proc Natl Acad Sci USA 2015, 111: 4221-6

　　2. Wu, DM Kuang, W Pan, Y Wan, X Li, D Wang, X Lao, and L Zheng. Monocyte/macrophage elicited NK cell dysfunction in Hepatocellular carcinoma is mediated by CD48/2B4 interactions. Hepatology 2012, 2013 57: 1107-16

　　3. J Xu, T Ding, Q He, X Yu, W Wu, W Jia, J Yun, Y Zhang, M Shi, C Shao, WD Pan, X Yin, J Min, SM Zhuang and L Zheng. In Situ molecular signature predict early recurrence in Hepatitis B virus-related hepatocellular carcinoma. J. Hepatol. 2012. 57: 313-21.

　　4. Q Zhao, DM Kuang, Y Wu, X Xiao, X Li, T Li, and L Zheng. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J. Immunol. 2012, 188;1117-24.

　　5. DM Kuang, Q Zhao, Y Wu, C Peng, J Wang, Z Xu, X Yin, and L Zheng. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J. Hepatol. 2011, 54:948-955. Editorial Comment in J Hepatol. 2011, 54:853-5

　　6. T Ding, J Xu, Y Zhang, RP Guo, W Wei, SD Zhang, CN Qian, and L Zheng. Endothelium coated tumor clusters are associated with poor prognosis and micrometastasis of Hepatocellular carcinoma after resection. Cancer, 2011, 117:4878-89

　　7. DM Kuang, C Peng, Q Zhao, Y Wu, L Zhu, J Wang, X Yin, L Li, and L Zheng. Tumor activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J. Immunol. 2010. 185:1544-9.

　　8. DM Kuang, C Peng, Q Zhao, Y Wu, M Chen, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory Th17 cells. Hepatology. 2010. 51:154-64.

　　9. JP Zhang, J Yan, J Xu, X Pang, MS Chen, L Li, C Wu, SP Li, and L Zheng. Increased intratumoral IL-17 producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 2009. 50:980-9.

　　10. DM Kuang, QY Zhao, C Peng, J Xu, JP Zhang, C Wu, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 2009. 206: 1327-37.

　　11. DM Kuang, Y Wu, N Chen, J Cheng, SM Zhuang, and L Zheng. Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood, 2007.