[10-27]生物膜与膜生物工程国家重点实验室学术报告:Neural Circuit Formation In Motor Systems
报告题目:Neural Circuit Formation In Motor Systems
报告人:Dr. Yutaka Yoshida ,Cincinnati Children’s Hospital Medical Center & Division of Developmental biology
邀请人:林鑫华 研究员 010-64807970
报告时间:2014年10月27日(周一)上午10:00
报告地点:中科院动物所 C101会议室
The Yoshida Lab is interested in understanding cellular and molecular mechanisms underlying neural circuit formation in motor systems.
Their projects focus on sensory-motor circuitry and corticospinal circuitry by using many techniques including molecular biology, mouse genetics, electrophysiology, behavior analysis, and trans-synaptic pseudorabies virus.
They have been trying to understand molecular mechanisms underlying axon guidance of sensory neurons as well as specificity of sensory-motor connections in the mammalian spinal cord. Their lab is also interested in understanding molecular mechanisms underlying CST axon guidance and connectivity between CSTs and spinal neurons in the spinal cord.
Representative Publications:
1、Yoshida, Y., Tanakam S., Umemori, H., Minowa, O., Usui, M., Ikematsu, N., Hosoda, E., Imamura, T., Kuno, J., Yamashita, T., Miyazono, K., Noda, M., Noda, T., and Yamamoto, T. (2000). Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell,103, 1085-97.
2、Gu C.*, Yoshida Y.*, Livet J., Reimert D.V., Mann F., Merte J., Henderson C.E., Jessell T.M., Kolodkin A.L., and Ginty D.D. (2005). Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science, 307, 265-8. (* : equal contribution)
3、Yoshida Y., Han B., Mendelsohn M., and Jessell T.M. (2006). PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron, 52, 775-88.
4、Fukuda T, Takeda S, Xu R, Kimura A, Sato T, Ochi H, Shibata S, Zirong G, Yoshida Y, Bando W, Sunamura S, Ma C, Xu C, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano O, Okawa A and Itoh H (2013). Sema3A regulates bone mass accrual through sensory innervations. Nature, 497, 490-3.
5、Bribián A., Nocentini S., Llorens S., Gil V., Mire E., Reginensi D., Yoshida Y., Mann F., and del Río J.A. (2014). Sema3E/PlexinD1 regulates the migration of hem-derived Cajal- Retzius cells in developing cerebral cortex. Nature Communications, 5, 4265.
6、Pecho-Vrieseling E., Sigrist M., Yoshida Y., Jessell T.M., and Arber S. (2009). Specificity of Monosynaptic Sensory-Motor Connections Encoded by Sema3e-PlexinD1 Repulsion. Nature, 459, 842-6.
欢迎老师同学参加!