报告题目：A Putative Tumor Suppressor Regulates Stem Cell Competition in Drosophila Testis

报告人：Prof. Steven X. Hou

National Cancer Institute of NIH

邀请人：林鑫华 研究员  010-64807970

报告时间：2014年9月3日（周三）上午10:00

报告地点：中科院动物所 C101会议室

Dr. Steven Hou received his Ph.D. from the University of Chicago in 1994 and completed postdoctoral training with Dr. Norbert Perrimon at Harvard Medical School in 1997. He became a Tenure-track Investigator at NCI-Frederick in September 1997 and received tenure as a Senior Investigator in May 2006.

His laboratory is interested in understanding how intercellular signals regulate development in embryo and regeneration in adult. They have been studying the JAK-Stat signaling in Drosophila. From his work and that of many others, it has emerged that the same signaling controls numerous decisions in development and also regulates stem cells in various adult tissues, including testis, kidney, stomach, and intestine. Current work is directed at understanding how adult stem cells are regulated in Drosophila and mouse in vivo genetic systems.

Journal Reviewer (ad hoc reviewer)

Cell、Science、Developmental Cell、Cell Stem Cell、Genes & Development、Development、Developmental Biology、Developmental Dynamics、Oncogene、Medical Science Monitor、Journal of Cell Biology、Genetics、The FASEB Journal、EMBO reports

Representative Publications:

1、  Hou, S. X., Chou, T. B., Melnick, M. B., and Perrimon, N. (1995).  The torso receptor tyrosine kinase activates raf in a Ras-independent pathway. Cell, 81(1):63-71.

2、  Hou, S. X., Melnick, M. B., and Perrimon, N. (1996). Marelle acts downstream of the Drosophila Hop/JAK kinase and encodes a protein similar to the mammalian STATs. Cell, 84(3):411-419.

3、  Hou, S. X., Goldstein, E. S., and Perrimon, N. (1997). Drosophila Jun relays the JNK signal transduction pathway to the DPP signal transduction pathway in regulating epithelial cell sheet movement. Genes Dev.,11(13):1728-1737

4、  Chen, X.,  Oh, S. W.,  Zheng, Z.,  Chen, H. W., Shin, H. H., and  Hou, S. X. (2003). Cyclin D-Cdk4 and Cyclin E-Cdk2 regulate the JAK/STAT signal transduction pathway in Drosophila.  Dev. Cell, 4(2):179-190.

5、  Singh, S. R., Liu, W., and Hou, S. X. (2007).  The adult Drosophila Malpiphian Tubules are maintained by multipotent stem cells.  Cell Stem Cell, 1(2):191-203.

6、  Zeng, X., and Hou, S. X. (2011). Kidney stem cells found in adult zebrafish. Cell Stem Cell, 8(3):247-249.

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